Interaction of 1-Adrenoceptor Subtypes With Different G Proteins Induces Opposite Effects on Cardiac L-type Ca Channel

نویسندگان

  • Jin O-Uchi
  • Hiroyuki Sasaki
  • Satoshi Morimoto
  • Yoichiro Kusakari
  • Hitomi Shinji
  • Toru Obata
  • Kenichi Hongo
  • Kimiaki Komukai
  • Satoshi Kurihara
چکیده

agonist, phenylephrine, showed 2 opposite effects on ICa (transient decrease followed by sustained increase). However, selective 1A-adrenoceptor stimulation ( 0.1 mol/L A61603) only potentiated ICa, and selective 1B-adrenoceptor stimulation (10 mol/L phenylephrine with 2 mol/L WB4101) only deceased ICa. The positive effect by 1A-adrenoceptor stimulation was blocked by the inhibition of phospholipase C (PLC), protein kinase C (PKC), or Ca /calmodulin-dependent protein kinase II (CaMKII). The negative effect by 1B-adrenoceptor stimulation disap-

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تاریخ انتشار 2008